Lately PowerBuilder has reinvented itself as a more modern development tool
As you may be aware, the company I work for does both PowerBuilder and RIA (Flex) application development. We actually create client/server and web-based front ends for the same application. Doing that has really emphasized just how much faster we can do development using PowerBuilder. Of course, we're originally a PowerBuilder shop, so one could argue we're faster using PowerBuilder because we know it better.
PBDJ article by Bruce Armstrong